Even though intracellular metabolism and activation of the ATP-sensitive K+ channels appear to be necessary for some signaling effects of FAs, a great amount of the FA responses in the ventromedial hypothalamic neurons are mediated by interactions with fatty acid translocase (FAT)/CD36. Translocase is a FA transporter/receptor that activates downstream signaling even in the absence of intracellular metabolism (Moulle et al., 2014).
Okay, I’ll admit I bailed just after the sriracha covered chicken costume, so maybe I missed it, but I wanted to ask: is Keto intended to be a permanent diet change? It seems very challenging, and as I was reading, I kept asking myself “How is this consistent with the concept of small sustainable changes?” Is it? I think it’s a great topic to cover, but how would you describe the relationship between the keto diet and NF philosophy regarding sustainability? Thanks!
Meanwhile, the KD induces a ketosis that is not a pathological but physiological condition occurring on a daily basis. Hans Krebs was the first to use the term “physiological ketosis” despite the common view of it as oxymoron (Krebs, 1966); this physiological condition, i.e., ketosis, can be reached through fasting or through a drastically reduced carbohydrate diet (below 20 g per day). In these conditions, glucose reserves become insufficient both for normal fat oxidation via the supply of oxaloacetate in the Krebs cycle and for the supply of glucose to the central nervous system (CNS) (Felig et al., 1969; Owen et al., 1969) (Figure (Figure1).1). It is well-known that the CNS cannot use FAs as an energy source because free FAs cannot cross the blood-brain barrier (BBB). This is why the brain normally uses only glucose. After 3–4 days without carbohydrate intake (KD or fasting) the CNS must find alternative energy sources as demonstrated by Cahill et al. (Owen et al., 1967, 1969; Felig et al., 1969; Cahill, 2006). These alternative energy sources are the ketones bodies (KBs): acetoacetate (AcAc), β-hydroxybutyric acid (BHB) and acetone and the process of their formation occurring principally in the mitochondrial matrix in the liver is called ketogenesis (Fukao et al., 2004). Usually the concentration of KB is very low (<0.3 mmol/L) compared to glucose (≅ 4 mmol) (Veech, 2004; Paoli et al., 2010). Since glucose and KB have a similar KM for glucose transport to the brain the KB begin to be utilized as an energy source by the CNS when they reach a concentration of about 4 mmol/L (Veech, 2004), which is close to the KM for the monocarboxylate transporter (Leino et al., 2001).
The current hypothesis is that the brain functions differently on ketones than on glucose, and this is what causes certain brains to reduce epileptic seizures. I would then also hypothesize that certain people who feel that “brain fog” lifted on ketosis is due to either placebo effect OR their brain actually functioning differently on ketones vs glucose.
Some Inuit consume as much as 15–20% of their calories from carbohydrates, largely from the glycogen found in raw meats. Furthermore, the blubber, organs, muscle and skin of the diving marine mammals that the Inuit eat have significant glycogen stores that are able to delay postmortem degradation, particularly in cold weather.
Long story short I’ve had the most terrible diet and mindset about food of anyone you’ve ever met my entire life. It consisted of pretty much only carbs. After studying them I’ve realized that it’s the reason that I got so big.. 570 at my known largest when I was weighed in the hospital. First time seeing a doctor in over 20 years. I bought a scale and tried random diets but couldn’t keep to them. I stayed at 530 ish for a year.
Look into cold showers and ice baths for relief from depression along with all the other benefits it provides. If you’re willing to push your comfort zone, you’ll find that cold showers/baths provide a monumental difference. There’s some research out there that identifies the benefits of combining specific ketogenic diets and ice baths. And I used this to increase gains in the gym, reduce inflammation, feel better in general, builds patience and raises tolerance levels. It’s impressive stuff. Cold and heat thermogenesis for the win (heat would be sauna/steam room, but cold is what helps you sleep better and will help you with depression). Good luck mate!
Then there’s medium chain triglycerides (MCT’s). Most dietary fat has to be converted into water soluble molecules that then need to enter the liver via your lymph system. Your liver then converts these molecules to fatty acids and ketone bodies. But unlike most other forms of dietary fats, MCT’s can enter your liver directly without having to go through your lymph system. This means that consuming MCT’s gives your body an opportunity to quickly produce ketone bodies.
Sharon M. Nickols-Richardson, PhD, RD, , Mary Dean Coleman, PhD, RD, Joanne J. Volpe, Kathy W. Hosig, PhD, MPH, RD, “Perceived Hunger Is Lower and Weight Loss Is Greater in Overweight Premenopausal Women Consuming a Low-Carbohydrate/High-Protein vs High-Carbohydrate/Low-Fat Diet,” The Journal of Pediatrics: Vol 105, Issue 9: 1433–1437; September 2005. http://www.sciencedirect.com/science/article/pii/S000282230501151X.
Now, there a few things you should know before you begin using KETO//OS. First, ketones naturally act as a diuretic, so you lose salt, potassium, calcium and magnesium, and it is generally encouraged to increase sodium intake with ketones. That’s why there is extra sodium added to KETO//OS. The combination of BHB with sodium also acts as a bit of a buffer to buffer natural ketone acidity.
Cancer is a broad term that refers to the presence of abnormal cells in the body that have the potential to grow and spread to other sites in the body. Cancer develops over time as cells acquire defects that affect their function, growth, proliferation and metabolism. Recently a list of ‘Hallmarks of Cancer’ was proposed by some of the leading investigators, Hannahan and Weinburg90 . These hallmarks include:
Check nutritionally-complete low-carb menus with under 50 grams of net carbohydrate per day to see what a ketogenic diet could look like. These menus are, however, going to be too high in protein for some people to remain in ketosis, and some of them may be a little high in carb if you have very poor carb tolerance. Keep in mind that ketogenic diets should always be tailored to the individual.
Lower HbA1c: HbA1c is an abbreviation for ‘glycosylated hemoglobin.’ Hemoglobin is a protein inside red blood cells, this means it is always exposed to the substances that circulate in the blood (i.e glucose). When glucose levels are high, glucose can bind to hemoglobin (i.e it becomes glycoyslated). As red blood cells survive inside the body for 100-120 days, the amount of glyosylated hemoglobin is a good indicator of long term glucose control. The healthy limit for HbA1C is below 5.7% (Source: WebMD).
I have that thing on a “real” ketogenic diet where I wake up at 3 am with my mind/heart racing and can’t sleep. It happens the very first day I reduce my carbs and continues as long as my carbs are reduced (5 weeks is the longest I’ve been able to put up with this to see if I could fix it and stay ketogenic). Magnesium and/ or cal-mag before bed does not help. Is carb loading at night the only hope for fixing this? I already take great care with bluelight and EMF.
Is it recommended to calculate our macros using the method suggested in the article to calculate yourself or by using the linked calculator? I get two different sets of numbers and am not sure which might be the better version. The main difference is amount of caloris and amount of protein to consume. The calculator gives me about 300 less calories, about the same amount of fat and carbs, but about 40 less protein than when I calculate myself.
I have been taking Ucan 30 Minutes before run and take UCAN 1 Hour into run and 1 hour later. Also take BCAA powder in 8 ounce liquid during run. I have been doing HFAT and LCARB diet. Problem i slow down after 1 1/2 hour during my long run. I need your advice help fueling my run after 14 miles. This my first Marathon, I have run 7 Half Marathon around 1.58.
I will begin a medically supervised weight loss program on Tuesday, that is intended to put me into ketosis via a very low calorie, high protein diet of shakes for two meals per day and one (controlled) regular meal. The overview of the program says to expect up to 2 weeks of foggyness and crankiness while getting in to ketosis. Will taking KetoCaNa 3 times a day for two days in advance of starting the diet (and during the introduction to the diet) help move me more quickly through the foggy, cranky phase? And should I also be eating (a ketogenic diet) during those two days or only drinking the KetoCaNa? My thanks in advance for any light you can shed on this!
Similar to the BHB salts and MCT’s from the KETO//OS I discuss above, powdered forms of ketones are excellent if you don’t want to completely eliminate carbohydrates or protein (which can be gluconeogenic when eaten in excess) or eat copious amounts of fats, but want to simultaneously maintain high levels of blood ketones. It may also be used to ease the transition into a ketogenic state, because it can help alleviate the fatigue and lethargy some people experience while making the transition from a glucose metabolism (carb burning mode) to ketone metabolism (fat burning mode).
I appreciate you sharing your story. In this day and age Keto is the holy grail for some. There are those of us though that do not respond well. I’m one of them. I couldn’t lose weight, I didn’t feel good (and that was after the Keto “flu”) and my periods were coming every 2 weeks (I’m 48 and peri-menopausal). What I did find, after the same soul searching, was that I do have some sort of weird physical reaction to wheat in any form. If I avoid it, I feel better. Whatever works, we’re all unique and what works for one will not work for all. That’s my big take away. I can appreciate that people have had success but something about going THAT low in my carbs created a stress response in my body. Also, I was needing to use my emergency Xanax a whole lot more. Thanks again for sharing!
The point of keto is to force your body to deplete its glucose (and the stored form, glycogen) so it will have to use body fat as a fuel source. It’s capable of making ketone bodies from your fat, which can replace glucose as an energy-storing molecule if necessary. To do that, you have to break apart fat molecules thus ‘burning’ the fat off. But here’s the thing: your body really really doesn’t want to run out of glucose. No glucose means starvation as far as it’s concerned—even if you're not feeling hungry, your body is still missing one of its key macronutrients. And when you’re (nutritionally) starving, your body will start to break down protein just to get those sweet, sweet carbs. Of course, you have a source of protein in your body already: your own muscles. “When in starvation mode, your body breaks down muscle in your body,” says Giancoli. “Ketosis is a way of trying to preserve that protein. It’s not ideal, but it’s your body’s way of saving you.”
The brain is composed of a network of neurons that transmit signals by propagating nerve impulses. The propagation of this impulse from one neuron to another is typically controlled by neurotransmitters, though there are also electrical pathways between some neurons. Neurotransmitters can inhibit impulse firing (primarily done by γ-aminobutyric acid, or GABA) or they can excite the neuron into firing (primarily done by glutamate). A neuron that releases inhibitory neurotransmitters from its terminals is called an inhibitory neuron, while one that releases excitatory neurotransmitters is an excitatory neuron. When the normal balance between inhibition and excitation is significantly disrupted in all or part of the brain, a seizure can occur. The GABA system is an important target for anticonvulsant drugs, since seizures may be discouraged by increasing GABA synthesis, decreasing its breakdown, or enhancing its effect on neurons.
THANK YOU! I’ve been doing Keto for 3 weeks and I don’t think this is the diet nor lifestyle for me. I’ve been having on and off Keto Flu that included painful headaches and constant bowel issues. I thought it would be over by the end of week 1, but I continued so I thought again at the end of week 2, but continued. It’s the end of week 3 and I’m not seeing any changes. I’m feeling just as tired if not more than when I wasn’t on Keto. My mood has been more snappy and aggressive than when I wasn’t on Keto. I just wasn’t happy. I already was super sensitive to salt & salty foods and now I’m even MORE sick of salt & salty foods. I missed my fruits and veggies like carrots which my pup & I often snacked on. I got super gassy and burped more these past 3 weeks than my entire life. My period was a mess and came 4 days earlier than normal and I haven’t had an odd period in over a year after getting diagnosed with mild PCOS. Attempting Keto really threw my body in for a loop and it’s been down hill ever since. I haven’t dropped in weight, the inches are still there, the bloating is still there. But now I have this fear of eating. I used to miss meals before and did IF for a while but now I miss even MORE meals and rarely eat which is just a recipe for weight gain when you’re consuming high fat. I’ve stocked my fridge with items I rarely ever bought: Sour Cream, Bacon, Cream Cheese, Heavy Whipping Cream. All because I needed to hit my fat macros.
Great article! As someone who just started a “ketogenic diet” two weeks ago, I am opting to hold off on using ketone supplements for the following reason. You state how “Keto-adaptation occurs when you have shifted your metabolism to relying on fat-based sources, instead of glucose (sugar) sources, as your primary source of fuel.” If the goal is to “switch” our body’s energy supply to ketones and one uses supplemental ketones, how do they really ever know if their body has successfully accomplished this goal if they are using supplemental ketones? Aren’t they getting a false sense of ketosis if their blood or breath tests show them above 0.5 millimolar through the use of the supplements? I understand that it may take me longer to reach ketosis naturally but I guess I see it was worth it to truly reap all of the benefits that you outline in your article.
But low-carb diets don’t work because of how people seem to think they work — more specifically, through something called the “insulin hypothesis,” which says that removing carbohydrates from your diet stabilizes insulin and blood sugar levels, subsequently increasing your metabolism and reducing your hunger. This hypothesis has failed several studies. A review study published in the European Journal of Clinical Nutrition in 2017 reported it as “carefully controlled inpatient feeding studies whose results failed to support key [carbohydrate-insulin] model predictions.” Sad.
-Cancer: Numerous studies have found that the risk for cancer increases with high blood sugar, which makes sense, since cancer cells feed primarily on glucose. This includes cancers of the endometrium, pancreas, and colon and colorectal tumors. Tim Ferriss recently hosted a fantastic article by Peter Attia about this very issue, and how ketosis may indeed be a potential cancer cure.
Happy Transformation Tuesday 🤗🎉 I can honestly say a year ago, I never would’ve imagined surpassing my goal of a 50 lbs weight loss, but here I am 75 lbs lighter and feeling better than ever! The girl on the left was ashamed of her body and would cover it up to make sure no one would see it. The NEW girl on the right is confident, empowered, and STRONG! I feel so lucky to have a great support system around me and thank all of you who have reached out for advice or sent kind words 😊 Keep Calm and Keto On Friends! . . . #keto #ketoweightloss #ketotransformation #ketogenicdiet #ketodiet #ketogenic #ketosis #ketolife #weightlosstransformation #weightlossjourney #weightloss #fitness #fitnessjourney #stronger #lowcarb #lowcarbdiet #lowcarblifestyle #lchf #transformationtuesday #weightlosstransformation #transformation #losingweight #fitnessmotivation #fitchick #weightlossbeforeandafter #beforeandafter #beforeandafterweightloss #samebutdifferent #motivation #curves
It is known that different dietary components exert some effects on gut microbiome composition, mainly in relation to obesity and inflammatory states. In general, a Mediterranean diet has a positive effect while a high-protein diet seems to have detrimental effects due to putrefaction phenomena (Lopez-Legarrea et al., 2014; Flint et al., 2015). Few data are available at this time about the effects of KD on gut microbiota. For example, a study by Crawford et al. (2009) investigated the regulation of myocardial ketone body metabolism by the gut microbiota and demonstrated that, during fasting, the presence of gut microbiota improved the supply of ketone bodies to the heart where KBs were oxidized. In the absence of a microbiota, low levels of KB was associated with a related increase in glucose utilization, but heart weight was still significantly reduced. The myocardial-mass reduction was completely reversed in germ-free mice feeded with a ketogenic diet. Regarding food control we can hypothesize that the particular metabolic state of ketosis could provide some benefit to weight and food control via synergic actions between butyrate production by gut bacteria and circulating high blood ketones (Sanz et al., 2015).
Lower fasting blood glucose: Fasting blood glucose gives a good snapshot of insulin sensitivity. In a healthy person, fasting blood glucose is , in pre-diabetes , and in diabetics this can exceed . A clinical study comparing a low calorie ketogenic diet to a low calorie diet showed that following the ketogenic diet resulted in lower blood glucose and lipid levels even if subjects were maintained at a constant weight 102 ,103.
If you give your body any more than the absolute minimum amount of protein that it needs, it will immediately break it down into carbs. This is why keto sites often give a guideline for not eating too much protein. The problem is that there’s no one guideline that works for everyone, and without specifically tailoring keto to your body it’d be easy to accidentally ingest too much protein.
Because tumor cells are inefficient in processing ketone bodies for energy, the ketogenic diet has also been suggested as a treatment for cancer. A 2018 review looked at the evidence from preclinical and clinical studies of ketogenic diets in cancer therapy. The clinical studies in humans are typically very small, with some providing weak evidence for anti-tumour effect, particularly for glioblastoma, but in other cancers and studies, no anti-tumour effect was seen. Taken together, results from preclinical studies, albeit sometimes contradictory, tend to support an anti-tumor effect rather than a pro-tumor effect of the KD for most solid cancers.
Achieving ketosis is a pretty straightforward, but it can seem complicated and confusing with all of the information out there.4If you want to learn more about ketosis and the scientific process around it, you can visit a very in-depth discussion about on Dr. Peter Attia’s website. Here’s the bottom line on what you need to do, ordered in levels of importance:
Many low-carbohydrate diets tout the benefits of being in a state of ketosis, which they claim results in weight loss. The idea is that by not eating enough carbohydrates to use as energy, your body will instead break down fat for energy. As a result, you will lose fat and weight. The idea of ketosis for weight loss, however, does not work as well in reality and comes with many health risks. Talk to your doctor before going on a diet that promotes ketosis.
I have never weighed myself after I started Keto though, I started out at 120kg and my goal was to hit 80kg eventually with no deadline. However, I was worried that if I hit it eventually, I would be less motivated to continue this lifestyle so yeah I have no idea what’s my weight now. I do know my waist has gone from 46” to 36” when I went to get new clothes.
The history of keto goes much farther than an attempt to stem weight gain during our fat-fearing era. In 1921, it was observed that fasting decreased incidence of seizure in epileptic patients. The same year, reports noted cognitive improvement and reduced seizure activity in epileptics who fasted for two to three days (fasting has been used as far back as 500 B.C. to treat epilepsy).
He is convinced that carbohydrate-heavy, low-fat diets are a major reason we're seeing high rates of diabetes, high blood pressure, obesity, and cancer. That's because a diet high in sugar can quickly raise insulin levels in the body. Over time, those spikes can lead to insulin resistance and eventually to long-term health issues like high blood pressure, Type 2 diabetes, inflammation, and obesity.
What it boils down to is this: You need to know yourself and your self-control. “If you’re able to have a higher-carb day that includes healthy carbs and be able to get back on track the next day, then it might work for you,” Devine says. “But if you’re somebody who kind of loses control when you get around sweet foods, and one donut means the entire case of donuts, you’re going to have trouble with it.”
The longer cholesterol circulates in your bloodstream, the higher the likelihood that it will dig its way into an endothelial wall and potentially contribute to atherosclerosis or plaque formation. This is why it’s so dangerous to eat a high-fat diet, but to also have your nightly dark chocolate bar, overdo it on the red wine, or have weekly “cheat days” with pizza, pasta, or sugar-laden ice cream.
The low glycaemic index treatment (LGIT) is an attempt to achieve the stable blood glucose levels seen in children on the classic ketogenic diet while using a much less restrictive regimen. The hypothesis is that stable blood glucose may be one of the mechanisms of action involved in the ketogenic diet, which occurs because the absorption of the limited carbohydrates is slowed by the high fat content. Although it is also a high-fat diet (with approximately 60% calories from fat), the LGIT allows more carbohydrate than either the classic ketogenic diet or the modified Atkins diet, approximately 40–60 g per day. However, the types of carbohydrates consumed are restricted to those that have a glycaemic index lower than 50. Like the modified Atkins diet, the LGIT is initiated and maintained at outpatient clinics and does not require precise weighing of food or intensive dietitian support. Both are offered at most centres that run ketogenic diet programmes, and in some centres they are often the primary dietary therapy for adolescents.
In some cases epilepsy cannot be treated successfully using anticonvulsant medications. In some cases where drugs have failed, the ketogenic diet has been widely documented to deliver transformative seizure control, reducing frequency by anywhere between 40-90%43. Whilst the exact mechanisms underlying the beneficial effect of the ketogenic diet are unclear, the hypothesised mechanisms include:
Swanson, a professor of neurology who has researched the impacts of ketogenic diets on inflammation in the brain, got curious about the ketogenic diet when trying to treat the inflammation that persists for days after a person suffers a stroke. When he tried inducing a ketogenic state in mice with stroke injuries, he said, “I was overwhelmed by the effect.” Blocking glucose metabolism worked to suppress inflammatory genes, which in turn helped stroke healing.
I completely agree with you. It’s all about moderation and by the sound of this blog, you went too deep into it and didn’t allow yourself exceptions which are encouraged on keto at times. Being too strict with any diet is not a good thing. It sounds more like a borderline eating disorder which I have suffered from in my past. Different things work for different people and It’s about finding the right balance which also includes exercise. People want to lose the weight fast without having to work at it. It’s not just about losing the weight though, it’s about creating a healthier way of living whether it be with keto or not. My last suggestion is never step on the scale to guide your progress. Gauge it by how your clothes are fitting and how you are feeling because in the end, THAT is the only thing that matters. Best of luck to you.
I think there is a lot more to the story than ketosis or very low carb for everyone. In my own experience, high carb works much better. I tried very low carb for a long without really feeling amazing, I then switched back to high carb and quickly lost weight and leaned out. I still eat high carb and my strength is better and I'm even leaner now. I find it very difficult to overeat (I obviously eat very 'clean diet').
macronutrient ratios in line: "Fat should be used as a satiating nutrient. People don't necessarily need to eat fat bombs and put extra fat on their food or in their coffee just to make it high-fat," says Mavridis. While this is a good strategy for when you're transitioning from a glucose-dependent diet to a fat-fueled one, it's not necessary once you’re fat-adapted, she adds. This is where intuitive eating comes into play. Learn to pay attention to your hunger cues. "If you’re feeling hungry shortly after a meal then you probably did not have enough protein or fat. But if you’re full and satiated, there is no reason to consume excess quantities of fat," explains the health expert.
What would your advice be to a high raw vegan who wants to try an HRV keto diet? The supps you recommended above look vegan, but aren’t the results based on those of omnis? Would they work the same way on vegans? Also I heard you mention in the recent Keto Summit that SE Asians need a little more carb and I happen to be one. I’m a petite 39-YO female and I’ve been raw for the past 11 years. I have been practicing intermittent fasting in the last 7 years and try to eat only twice a day. Up to how many grams of carbs can I consume to get into ketosis?
C8 is the rarest MCT found in coconut oil, comprising about 6% of coconut oil. It has potent anti-microbial properties (way more potent than lauric acid) to help you maintain a healthy gut, and it is the fastest MCT to metabolize in the brain. (hence the name Brain Octane). Your liver does not need to process C8, and it only takes the steps for your body to turn it into ATP cellular energy (sugar takes 26 steps). You would need 18 tablespoons of coconut oil to get just one tablespoon of Brain Octane.
Here's what I learned about the keto diet: You essentially swap a high-carb diet, which most Americans tend to eat, for a diet that's very high in fat (the healthy kinds), moderate in protein, and very low in carbohydrates. The idea is that you change the source from which your body gets its energy (and burns calories) from glucose (from carbohydrates) to ketones (from fat). This shift doesn't happen after one bulletproof coffee, though. It usually takes a few days of eating this way for your body to reach ketosis—where it's looking to fat as its first source of fuel. Once there, though, your body "will be burning fat all the time," says Dr. Axe. "It doesn't matter if you're working out or sleeping, or what you're doing, your body continues to burn fat in ketosis."
Also, when you eliminate sugar and high-carb foods from your daily diet, "your body is able to heal itself and detox from the accumulated inflammation that it is constantly fighting," That means less brain fog, improved cognition and brain health. Consequently, the improved mental clarity makes it easier for you to make smart food choices, adds the nutritionist.
If you want to reach ketosis, the most important thing is to avoid eating most carbs. Keep your carb intake to around 20 to 50 grams per day for the diet to work most effectively. You’ll want to stock up on low carb foods, and be mindful of low carb veggies and fruit. Limit your intake of root vegetables like mushrooms and squash, berries and citrus fruits. Here’s a low carb food list for the keto diet.
After increasing water intake and replacing electrolytes, it should relieve most all symptoms of Keto Flu. For an average person that is starting a ketogenic diet, eating 20-30g of net carbs a day, the entire adaptation process will take about 4-5 days. My advice is to cut your carbs to fewer than 15g to ensure that you are well on your way into ketosis within one week. If you are experiencing any more keto flu symptoms, double check your electrolyte intake and adjust.
Awesome info. I’ve been LCHF moderate protein (about 1 g per lean lbs/mass) and 50-100g of carbs for about a year. I’d consume around 2500 cals. I’m active 4-5 days a week (60-90 min cycling sessions) I started using MCT/Butter coffee. It surpressd my appetite and I would only eat whole food at lunch/dinner…still LCHF, but since my appetite was lower I was only takin in about 1800 cals. After about 2 weeks I started to gain body fat. Do you think the reduced caloric intake is the culprit? Should I “force” myself to eat…maybe up the MCT intake to make up the difference?
The ketogenic diet is amazing for losing weight and improving your health, so stick with it and don’t be afraid to make changes as needed. Track what you eat, stick within your keto macros, and test your ketone levels frequently to make sure you’re staying in ketosis. Most of all, give your body time to respond to the great changes you’re making for it.