Ketones are a special type of fat that can stimulate the pathways that enhance the growth of new neural networks in the brain. A ketogenic diet is one that is high in fats, and this diet has been a tool of researchers for years, used notably in a 2005 study on Parkinson’s patients finding an improvement in symptoms after just 28 days. The improvements were on par with those made possible via medication and brain surgery. Other research has shown the ketogenic diet to be remarkably effective in treating some forms of epilepsy, and even brain tumors.
I originally started this “diet” because I am the Maid of Honor in my best friends wedding. She made me order a size down than I was comfortable with and it fit, if you didn’t zip it up. I tried it on a couple weeks later and it REALLY didn’t fit, I couldn’t pull it up past my hips. I was mortified and super embarrassed, how was I going to be in this wedding if I can’t even fit in this dress. Cut to now, I just tried on my dress and it’s too big! I’m so excited that I have to get it altered.
You indicate that exogenous ketones do not shut down the ability, of your body, to oxidize fat. Is that to say it does not have an effect on your body at all? My specific question is… does my body oxidize less fat, when supplementing with exogenous ketones? I think you indicate in your article that it could. I would expect it to, in that if I supplement then my body would not “need” to oxidize the fat to provide the energy.
Lasty, why are you doing keto? Because a friend did it? Everyone is different. Keto didn’t work for me (and doesn’t work for most people in the long run.) High carb works much better for me. I suggest listening to your body and letting it guide you in your food choices. You will end up much happier. It starts with learning to love yourself as you are. If you don’t, you’ll never be happy, no matter what weight you are.
There are many benefits to keto, including health benefits. I’ve lost 60bs and many of my health issues cleared up. I disagree with this article as it’s only one persons experience and there’s a lot of fear mongering here. Surgeons and doctors prescribe this way of living for diabetics and major surgery patients for their best chance of survival. There’s no way they would do this if it were harmful. Keto is not for everyone but it is for a lot of people and this blog deters people who could be genuinely interested in living a healthier lifestyle.
I'd recommend starting with glucose and hemoglobin A1C, along with a good multi like https://bengreenfieldfitness.com/multi and a fish oil like the one at greenfieldfitnesssystems.com – Anyways, I'd be happy to help you via a personal one-on-one consult. Just go to https://bengreenfieldfitness.com/coaching. and then choose a 20 or 60 minute consult, whichever you'd prefer. I can schedule ASAP after you get that.
It's worth noting that the review focused on low-carbohydrate diets, which are not always ketogenic. To be sure, there are balanced ways to adopt the ketogenic diet, and it can beneficial to some. In addition to its proven weight-loss effects that can be especially helpful for obese people, the diet is also a proven treatment for children with epilepsy. That's because the state of ketosis produces a natural chemical called decanoic acid, which can reduce seizures.
I have read your article and lots of other stuff on Keto, but I still don’t understand why it has to be so high in fat? I am on a calorie controlled diet which should also be pushing me into ketosis (Optifast + veges) nutritionist suggestion to go hard for a month. But after that was looking at moving to a Ketogenic diet. I am just having a hard time with understanding why it has to be high fat. Can you help me understand? Also love your writing style (particularly referencing Ace Ventura).
I think there is a lot more to the story than ketosis or very low carb for everyone. In my own experience, high carb works much better. I tried very low carb for a long without really feeling amazing, I then switched back to high carb and quickly lost weight and leaned out. I still eat high carb and my strength is better and I'm even leaner now. I find it very difficult to overeat (I obviously eat very 'clean diet').
I follow keto and got off 2-Insulins that equaled 5 shots per day and metformin pills @ 1000 mg twice a day and 1 kidney med. Keto has changed my life fior the better. I’m also a health coach for weight loss and nutrition and everyone is different when it comes to weight loss and health. My final #s -95 lbs/22 pants to size 8 and 2x too to small and feel and look great inside and out.
Jump up ^ Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM. The efficacy of the ketogenic diet—1998: a prospective evaluation of intervention in 150 children. Pediatrics. 1998 Dec;102(6):1358–63. doi:10.1542/peds.102.6.1358. PMID 9832569. https://web.archive.org/web/20040629224858/http://www.hopkinsmedicine.org/press/1998/DECEMBER/981207.HTM Lay summary]—JHMI Office of Communications and Public Affairs. Updated 7 December 1998. Cited 6 March 2008.

"I start my day with coffee and heavy whipping cream. My first meal of the day is in the afternoon and is usually something small like leftovers or some eggs. It’s about getting in protein and making sure whatever I eat is quality and tastes delicious. For dinner, I have a bigger meal which is always an animal protein with a side of something green like spinach or broccoli."
Long-term use of the ketogenic diet in children increases the risk of slowed or stunted growth, bone fractures and kidney stones.[3] The diet reduces levels of insulin-like growth factor 1, which is important for childhood growth. Like many anticonvulsant drugs, the ketogenic diet has an adverse effect on bone health. Many factors may be involved such as acidosis and suppressed growth hormone.[37] About 1 in 20 children on the ketogenic diet will develop kidney stones (compared with one in several thousand for the general population). A class of anticonvulsants known as carbonic anhydrase inhibitors (topiramate, zonisamide) are known to increase the risk of kidney stones, but the combination of these anticonvulsants and the ketogenic diet does not appear to elevate the risk above that of the diet alone.[38] The stones are treatable and do not justify discontinuation of the diet.[38] Johns Hopkins Hospital now gives oral potassium citrate supplements to all ketogenic diet patients, resulting in a sevenfold decrease in the incidence of kidney stones.[39] However, this empiric usage has not been tested in a prospective controlled trial.[9] Kidney stone formation (nephrolithiasis) is associated with the diet for four reasons:[38]

Devine says not to jump right into keto cycling. “I would definitely not try keto cycling until you’re about two to three months into your keto diet,” she says. “That's because you need to make sure your body is fat adapted so that it can get back into ketosis easily.” In her practice, Devine has noticed that if the body is used to being in ketosis, it’ll snap back more quickly after eating a carb-heavy meal than if a person is new to keto, though there’s no firm research to support that this is always the case.
At one point in the early 2000s, approximately 10 percent of the country was on a low-carb diet. That’s insane. What’s more, people actively started avoiding carbs even if they weren’t on a diet. “A year ago, if you asked consumers what they watch, 11 percent would have said carbs,'' Michael Polk, the chief operating officer at Unilever-Best Foods, told The Times. “Today if you ask, 40 percent of consumers say they are watching carbs. In our opinion, this has evolved into a major shift in consumer behavior.” Atkins was able to build an industry out of his diet advice: Atkins Nutritionals, which cranked out low-carb meals and snacks, was at one point valued at approximately half a billion dollars.
You likely heard that a high-fat, low-carb keto diet can melt fat. Because it contains virtually no carbs, a ketogenic diet forces your body to burn fat instead of glucose for fuel. Ketosis is the state your body enters when your liver effectively breaks down fats into ketones to use as energy. Without glucose, your body doesn’t have all the highs and lows that lead to hunger pangs, energy crashes, and cravings. Instead, your blood sugar levels stay stable. Your body also sheds excess weight — fast.
Implementing the diet can present difficulties for caregivers and the patient due to the time commitment involved in measuring and planning meals. Since any unplanned eating can potentially break the nutritional balance required, some people find the discipline needed to maintain the diet challenging and unpleasant. Some people terminate the diet or switch to a less demanding diet, like the modified Atkins diet (MAD) or the low-glycaemic index treatment (LGIT) diet, because they find the difficulties too great.[41]
There seems to be an assumption sometimes that the more obsessed with losing weight we are, the lower our self image must be. Mine’s just fine….I’m 63 and I am happy to look 63….but I do NOT See the sense in inviting all the very well researched obesity related health issues into my life. Getting older is hard enough on the bod! So yes, I’m incredibly keen to drop more weight (obsessed if you like) but only because I want to deal with joint pain, avoid diabetes and cardiovascular disease … and simply to function better for longer.
I’ll warn you: when you first start using BHB salts like KetoCaNa, it can cause some temporary GI upset until you get acclimated to use. For me, this manifested in just a little bit of gas and bloating that subsided after about one week of use. Additionally, you should know that this product contains salt, so it counts as part of your daily salt intake.

On the ketogenic diet, carbohydrates are restricted and so cannot provide for all the metabolic needs of the body. Instead, fatty acids are used as the major source of fuel. These are used through fatty-acid oxidation in the cell's mitochondria (the energy-producing parts of the cell). Humans can convert some amino acids into glucose by a process called gluconeogenesis, but cannot do this by using fatty acids.[56] Since amino acids are needed to make proteins, which are essential for growth and repair of body tissues, these cannot be used only to produce glucose. This could pose a problem for the brain, since it is normally fuelled solely by glucose, and most fatty acids do not cross the blood–brain barrier. However, the liver can use long-chain fatty acids to synthesise the three ketone bodies β-hydroxybutyrate, acetoacetate and acetone. These ketone bodies enter the brain and partially substitute for blood glucose as a source of energy.[55]
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This was a great article! Thanks so much for clarifying about the KETO diet. I am a thin woman who cannot really gain weight, even though I eat a pretty well rounded diet. My fiancé mentioned the KETO diet because he wants to lose weight. He also would like us to eat dinner together and eat the same things. The latter was mentioned before the KETO diet came into conversation. I already had misgivings about the KETO diet because I feel like my body needs carbs. I do not eat much meat at all and most of my protein comes from beans and other plant foods. Now, I KNOW that the KETO diet is not for me. I am already concerned with losing muscle mass due to aging and changing biologically through peri-menopause and not exercising as much as I should. I LOVE sweet potatoes and other foods you mentioned and could not see giving them up. Anyway, thanks for the information about your experience!

"I work in a really corporate environment where there's often donuts and cupcakes around. My coworkers say, 'Nobody will know if you just a have a cupcake,' but I will know! It’s not about beating the system or sneaking in cheat meals. I know the food is going to make me feel bad all day and it's not worth it to me. There’s always a line of people at the coffee machine at 2 o’clock in the afternoon because they’re all so tired after lunch."

I’m honestly a little skeptical about it the idea of keto permanently. My brief glance at the literature seems to imply that it can have side effects of kidney stones, skeletal fractures, and slow the growth rate of children, but that was a study on kids with epilepsy (which it treated very effectively), so who knows how that applies to adults. And the other studies I found dealt with overweight and obese subjects, so it may be hard to find something on the long term effects on otherwise healthy adults.


Still, I enjoy cooking and I plan my meals on the regular anyway. With a keto food list in hand and advice from Dr. Axe in my mind, I filled my grocery cart with family-size versions of what I regularly buy (apples, berries, nut butter, kale), and a lot more meat than I ever have in my cart at one time (ground lamb, chicken, REAL bacon). What was missing? Some of my usual high-carb items, like whole-grain English muffins, orange juice, butternut squash, and tortilla chips.
Including greens powder in your supplement regimen is an excellent way to boost your intake of nutrient-dense vegetable. Most greens powders come with a mixture of powdered plant-based nutrients from spinach, spirulina, chlorella, broccoli, wheatgrass and more that are all beneficial for health. Adding greens powder to your drinks, shakes, and smoothies is a good way to help optimise nutrition and promote fat loss, especially when on a keto diet.
For some, ketosis can cause more negative than positive side effects. Dorena Rode, a 52-year-old author, and speaker from Occidental, California, tried the diet for a month and experienced heart palpitations and dizziness. Unlike Drew, Rode says her cholesterol increased from 192 to 250 mg/dL after she introduced more fat into her diet. (Less than 200 mg/dL is considered desirable, while anything over 240 mg/dL is considered high.)
Protein: Keep in mind that keto is high-fat, and not high-protein, so you don’t need to eat very much meat. Too much protein turns into glucose in the body, making it harder to stay in ketosis. Stick to fatty cuts of grass-fed, pasture-raised, or wild meat, and wild-caught fish. Red meats, offal/organ meats, pork, eggs (preferably pastured), fish, shellfish, and whey protein concentrate.
Jump up ^ Ketogenic "eggnog" is used during induction and is a drink with the required ketogenic ratio. For example, a 4:1 ratio eggnog would contain 60 g of 36% heavy whipping cream, 25 g pasteurised raw egg, saccharin and vanilla flavour. This contains 245 kcal (1,025 kJ), 4 g protein, 2 g carbohydrate and 24 g fat (24:6 = 4:1).[17] The eggnog may also be cooked to make a custard, or frozen to make ice cream.[36]
It’s important to remember weight loss alone doesn’t necessarily cause all health markers to improve, and a diet causing weight loss does not mean it’s appropriate and healthy for everyone. Some foods are better than others at making weight loss and maintenance easier for different people, so balancing a diet is a fairly personalized thing. If your doctor gives you the green light and keto works for you, do it. If low fat works for you, do it. If plant-based, paleo, Mediterranean, or one of the zillion other diets help you improve your health and your relationship with food? Do it. There’s no one right way to eat for everyone, just as there is no miracle diet plan for weight loss.
As you’ve said and others, I did this for weight loss not medical purposes. While it got me to the weight I am, I’m now having to watch my carbs and protein and calories. I’m stuck at the same weight for now, but my doctor said that my body may not level out until I’m at my goal weight (around 100 more to go). I’m not necessarily complaining, but this crap is scary when experiencing it. And now if I eat slightly too many carbs, the wrongs carbs, too little protein, or anything that my body disagrees with, I crash.
This doesn’t mean that you can never have some of your favorite foods again.  Once you get past the adaptation phase and you have tested that you are in Ketosis, you can start experimenting with Keto versions of the foods you don't want to give up. Here are a few simple Keto recipes to start with. If you're looking for ready-to-eat Keto-friendly options, check out Country Archer Meat Sticks, Cuvee Coffee and FBOMB nut butters.
The ketone bodies are possibly anticonvulsant; in animal models, acetoacetate and acetone protect against seizures. The ketogenic diet results in adaptive changes to brain energy metabolism that increase the energy reserves; ketone bodies are a more efficient fuel than glucose, and the number of mitochondria is increased. This may help the neurons to remain stable in the face of increased energy demand during a seizure, and may confer a neuroprotective effect.[55]
Consume more beef and high-fat dairy. These keto foods contain high amounts of a fatty acid called Conjugated Linoleic Acid (CLA). CLA has been found to improve fat loss by a variety of different mechanisms. To get as much CLA as possible, source your dairy and beef from 100% grass-fed cows. CLA content is 300-500% higher in beef and dairy from grass-fed cows, compared to grain-fed cows.
The situation for Type II diabetics is different because some insulin production remains and some cells of the body can still respond to insulin. It is worth noting that insulin sensitivity can be different between the different tissues of the body such as liver, adipose tissue and muscle. A small amount of insulin release can help to prevent development of DKA unless the body is totally insulin resistant. Insulin resistance is a term used to indicate that for a given amount of insulin, the cells of the body are less responsive and take up less glucose. This means that blood glucose levels remain higher for longer when insulin resistant Type II diabetics eat a carbohydrate rich meal. Over time, the pancreas secretes more insulin to compensate for reduced insulin sensitivity, which can damage the insulin producing (beta) cells. Furthermore, having high blood glucose can lead to a number of side effects:
The former NFL star loves adding avocados to his daily diet as part of the keto program. “I have to take in a lot of fat, and the number one fat comes from avocados,” he told GQ. “It’s a super food. And even if that’s not your diet, it’s incredible food for you. I put them in my smoothies, guacamole, a bunch of different things. For me it’s more than just trying to stay in shape for sports, it’s a way of life, of trying to be healthy.”
Doctors at the Mayo Clinic created a formula that manipulated the ketogenic effect that came with complete fasting by instead limiting a patient’s intake of carbohydrates. This was the genesis of the ketogenic diet. To manage childhood epilepsy, the prescribed diet consisted of one gram of protein per kilogram of body mass — a max of 15 grams of carbs — and the rest of the calories from fat. Et voila: the ketogenic diet was born.
The addition of MCT powder to ketones serves the purpose of maintaining endogenous production of ketone bodies by stimulating fatty acid oxidation in the liver, which then causes the production of even more ketone bodies. In this transcript from a podcast with Dr. Dom D’Agostino it is mentioned that MCT’s cross the blood-brain barrier straight to the brain. So not only are the ketones being used by the brain as an alternative fuel but so are MCT’s.
Whilst the diet is broadly acknowledged to be safe strategy where medications have failed, side effects such as kidney stones, hyperlipidemia and can occur47. Furthermore, maintaining dietary adherence in young school age children can be very challenging for caregivers. Exogenous ketones may be an alternative or a adjunct to the ketogenic diet in epilepsy. Early work suggests that exogenous ketones could have antiseizure effects. Injection of the ketones acetoacetate and acetone have been found to have anticonvulsant properties in animal models48, and an acetoacetate diester was found to protect against seizures in rats exposed to high levels of oxygen49. Further studies are required to understand specifically how ketone bodies affect seizure control, however for children who experience daily seizures a combination of the ketogenic diet and exogenous ketones could be helpful to manage their condition.    
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The 2017 meta-analysis by Drs. Kevin Hall and Juen Guo provide us with very convincing data, but we must also consider the fact that the data came from studies where all the food was provided by the scientists. Although this is a great way to assess the difference between low-carb and high-carb diet, this does not simulate the real-world effectiveness of each diet. For this reason, we must investigate data from less strict studies. In other words, we need to look at what happened when subjects were told to follow a specific diet on their own.
I was Keto for 6 months and did not lose a pound ! Couldn’t figure out WHY – I was doing 36hr fast, staying in my macros etc… So after 6 months of NO progress I switched it up , and lost 11 pounds in 1 month. AND that was with adding in more carbs, grains, fruit etc.. I think Keto works for some and those that are very large will initially drop as they would on any diet plan cutting out the junk. It wasn’t for me .
Day 5: As fate would have it, 3 p.m. rolls around and we get a message that there are cookies in the conference room. I have been snacking on keto-approved foods like Granny Smith apples (the tart green apple has way less sugar than, say, a red Gala), and full-fat cottage cheese with blueberries (where have you been all my life, snack?) with no real trouble with cravings. But just knowing there are cookies that I can't eat makes me feel a little cheated.  (Though These Low-Carb Keto Desserts Help With That.)
Day 13: I have a love-hate relationship with this intermittent fasting thing. I think it's "working," and by that I mean I'm losing some weight. (Plus, improved body composition and definition can come with weight loss.) When I ask Dr. Axe if I should attribute my success to keto or IF, he says both. "I would say 80/20 it's more strongly in the favor of keto, but intermittent fasting does help as well," he says. The fat-burning capabilities of keto have more strength behind it when it comes to weight loss, specifically, he adds, but the intermittent fasting can be great for digestion and just feeling good.
Cancer is a broad term that refers to the presence of abnormal cells in the body that have the potential to grow and spread to other sites in the body. Cancer develops over time as cells acquire defects that affect their function, growth, proliferation and metabolism. Recently a list of ‘Hallmarks of Cancer’ was proposed by some of the leading investigators, Hannahan and Weinburg90 . These hallmarks include:
Experts are split on whether the keto diet is a good idea. On the one hand, Lori Chang, registered dietitian and a supervisor at the Center for Healthy Living at Kaiser Permanente West Los Angeles, says using a “cleaner” source of energy—ketones rather than quick-burning carbohydrates—can improve mood and energy levels. When you eat refined carbohydrates or just too many carbs in general, the blood is flooded with excess insulin, Chang says. "This can lead to a blood sugar rollercoaster that stresses the body and negatively impacts energy levels and mood. When you’re in a state of ketosis, however, ketone bodies don’t require insulin to cross the blood-brain barrier, which wards off unfavorable blood sugar levels."
Ditto! I have an autoimmune disorder which includes rumathoid arthritis. Since I have been on Keto I suffer less pain and my blood pressure is now normal. Is it a cure all? Nope, it is a easy to follow life style change I recently turned 62 and I almost feel like a teenager again. Dang it, I’ve lost so much weight and now I’m going to have a neck lift to cut off the excess loose skin. I hate when that happens! 🙂

The keto diet is known for helping people lose a few pounds very quickly, says Becky Kerkenbush, RD, a clinical dietitian at Watertown Regional Medical Center. Carbs hold on to more water than protein or fat, so when you stop eating them, your body releases all that extra H2O by making you pee more. As a result, the scale might read a few pounds lower, and you may look a bit leaner.
Some people do not produce enough ketones to show up in their urine. If you are experiencing a reduction in your appetite and an improvement in well-being and are losing weight or your clothes are feeling looser, there is no need to do anything differently. Remember, the lipolysis testing strips (LTS) are tools; making them change color is not the sole object of the game. If you are not losing weight, you either have a strong metabolic resistance to weight loss or you are consuming "hidden" carbohydrates in the form of sweetened salad dressing, breading, etc. Then follow Induction strictly for five days. If the LTS still haven�t changed even slightly, make sure you are not consuming excess protein and measure your salads to make sure you are not eating too many veggies. Still no change? Try cutting out tomatoes and onions, which are relatively high on the glycemic index. You may also benefit from nutritional supplements such as L-carnitine, hydroxycitric acid (HCA), and chromium - all of which aid in hunger reduction or weight loss. You may also need to step up the frequency and intensity of your exercise program.
Lately anecdotal evidence has been building that a ketogenic diet can yield transformative results with respect to weight loss: with people taking to social media to share ‘before and after keto’ photos and to stories of ‘how keto changed my life.’ Despite this, concrete clinical evidence confirming that a ketogenic diet is superior to any other diet that creates a calorie deficit is lacking. At the moment the most accurate statement is that ‘the best diet for you is one you can stick to,” a pattern of eating that maintains a small calorie deficit should, over time, lead to weight loss. 
Hey Alex, thanks for commenting and great to have you as a new listener! For this kind of thing, because it requires so going into detail, I'd suggest you book a consult with me by going to
We can say that no species, including humans, could have survived for millions of years without the ability to withstand brief periods of hunger or starvation (Amen-Ra, 2006). These periods of fasting are themselves ketogenic (McCue, 2010) during which the concentrations of insulin and glucose decrease while that of glucagon increases in the attempt to maintain normal blood glucose levels. When the body passes from a condition of food abundance to one of deprivation (or else via VLCKD simulated deprivation), there is, with a slight delay, an increase in the concentration of free FAs as well as KB in the blood. Thus, from this point of view KD could be compared to caloric restriction for fasting. These manipulations of nutrients, both in quantity and quality, seem to not only act on blood glucose/KB level but also to promote changes in metabolic pathways and cellular signaling. How this kind of metabolic condition (ketosis) can affect satiety and hunger mechanisms is still a matter of debate.

The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories[Note 1] to maintain the correct weight for age and height. The classic therapeutic ketogenic diet was developed for treatment of paediatric epilepsy in the 1920s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant medications. This classic ketogenic diet contains a 4:1 ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains and sugar, while increasing the consumption of foods high in fat such as nuts, cream, and butter.[1] Most dietary fat is made of molecules called long-chain triglycerides (LCTs). However, medium-chain triglycerides (MCTs)—made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oil, which is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.[4][5]
I also found that I put on weight quite easily while eating low carb. I thought that being in ketosis meant I was burning my body fat, when in fact, I was just burning the fat that I was eating. Eventually, my female sex hormones tanked and I started gaining weight no matter what I did. I firmly believe this was because my body was in such a state of stress from not eating enough carbs.
Swanson, a professor of neurology who has researched the impacts of ketogenic diets on inflammation in the brain, got curious about the ketogenic diet when trying to treat the inflammation that persists for days after a person suffers a stroke. When he tried inducing a ketogenic state in mice with stroke injuries, he said, “I was overwhelmed by the effect.” Blocking glucose metabolism worked to suppress inflammatory genes, which in turn helped stroke healing.
The participants had an age range of 22 to 75 years with an average age of 46.8 years. They had a BMI range of 30 to 45 kg/m2. About 88% of the participants were female and 51% were of African origin; thus, it was considerably more diverse than the prior study. They were also free of cardiovascular and renal complications including type 2 diabetes, cardiovascular diseases, and kidney disease as well as significant weight-loss in the past six months.
Type II diabetics can reduce their risk of developing these complications by keeping blood glucose levels within a healthy range (4.5 - 6.5 mM). This can be achieved using insulin injections, but using insulin is not without side effects (i.e hypoglycemia requiring assistance and weight gain)101. Therefore dietary carbohydrate restriction is likely to be a good lifestyle change to help with diabetes management,. Companies such as Virta Health are popularising this approach to diabetes management and pioneering the use of technology to improve compliance. The benefits of carbohydrate restriction include:
I’m glad I came across this post. One of my friends was advised to do Keto by her doctor due to insulin resistance and was talking about how much weight she has lost in a very short time period and I thought maybe it would be worthwhile to try myself for at least a jumpstart to weight loss. The more I read about the diet, the more concerned I was that eating that much fat would be detrimental to me because my cholesterol is slightly higher than normal, my family has a history of heart disease, and I had my gallbladder removed two years ago. It seems that after reading this post, my concerns may have been warranted. I’m glad to see something to balance out all of the positive press that keto seems to be receiving these days and give an alternate point of view. I’ll keep looking for a balanced diet that will work for me. Thank you.
Forget the word “diet”. I’m eating low carb/keto for about two months now. Before, I was always hungry, always thought about food. My stomach never felt good. I had awful heartburn all the time, so I took Prilosec every other day! Now the inflammation is gone because I lost all the “water weight”. Yay!! The side effects are amazing. I feel better than I have in years. No more heartburn! This isn’t a diet. It’s a new way of life for me, and I’ll never go back.
For any long 90+ minute workouts or competitions for which glycogen depletion is a potential issue, use Glycofuse, but use half of the recommended serving of it, and add one scoop of Catalyte electrolytes, one scoop of Aminos, and one serving of medium chain triglycerides in the form of Brain Octane, KetoCaNa or KETO//OS (pick your poison, it’s up to you).

Therefore the combustion enthalpy (∆H) of each fuel is an important factor in the energy it can provide to the cell. When expressed as the energy per 2 carbons in the molecule, ketones (BHB) have a higher combustion enthalpy (∆H) than pyruvate, lactate and glucose (see table). This means that the amount of energy that could possibly be transferred to ATP is higher than for those other substrates:
So I was following a ketogenic plan for the past month in an effort to lose about 4-5% body fat and try to turn down the inflammation in my body to help with my hashimotos and psoriasis. I don’t eat meat, so it was ALOT of eggs (from the farmers market), primal mayo, wild caught salmon and cold smoked lox (vital choice), brain octane oil, coconut oil, avocado oil with VERY little carbs…like 85% fat, 10% protein and 5% TOTAL carbs. I was eating about 1100-1200cal per day and BELOW 18g TOTAL carbs…Couldn’t get above .6 in AM fasted blood ketones or below 80 fasted blood sugar. I do 90min of Ashtanga yoga (primary and half of second series) 5 days a week and 20-30min weight/HIIT style workouts about 3-4 days per week (Kettlebell, jump rope, plyometrics and free weights). I take Concentrac Trace Minerals along with my d3/k2, l-carnitine, l-glutamine, forskollei, green pastures butter/cod liver oil and probiotics. I have been at the Bulletproof Conference this weekend and I bought the new Bulletproof exogenous Ketones to try.
Pro Tip: On keto, you don’t need to fixate on a precise calorie count because weight loss comes from getting within your ideal calorie range. However, it will help to pay attention to your macronutrient proportions: 5 percent of calories from carbs; 20-30 percent from protein; and 70-80 percent from fat. Davoodi adds that drinking plenty of water to break down fat is particularly important on a high-fat diet like keto.
Jump up ^ Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM. The efficacy of the ketogenic diet—1998: a prospective evaluation of intervention in 150 children. Pediatrics. 1998 Dec;102(6):1358–63. doi:10.1542/peds.102.6.1358. PMID 9832569. https://web.archive.org/web/20040629224858/http://www.hopkinsmedicine.org/press/1998/DECEMBER/981207.HTM Lay summary]—JHMI Office of Communications and Public Affairs. Updated 7 December 1998. Cited 6 March 2008.
I’ve been on the Wheat Belly Diet over 2 years. You have to read the book on it by Dr. Allen Wolfelt. It works. Basically you’re cutting out grains do to the GMO. No wheat or corn, cousins of, or biproctucts of. It took some getting use to, and adjustments. I started out with certain things and worked my way. You’d have to read his book. I’m making it my life style, rest of my life.
Also, take special note of sugar alcohols like sorbitol, mannitol, xylitol, and isomalt. Sugar alcohols are derived from plant products (ie., fruits and berries), though their carbs are uniquely altered through chemical processing. While sugar alcohols provide fewer calories than table sugar, people often overeat them because they are labeled as “sugar-free” or “no sugar added” foods. This is problematic because they can still spike blood glucose levels due to their carb content. You still need to account for them in your diet plan.[2] Your best bet is to go with erythritol because it doesn’t cause blood sugar or insulin spikes.
For a given quantity of fuel, the maximum amount of work that can be obtained from that fuel in a closed system is called ‘the Gibbs free energy’ (G). This takes into account the inherent ‘heat’ (combustion enthalpy (H)) and a property called entropy (a measure of tendency towards ‘disorder’ (S). The change in Gibbs free energy (∆G) is related to the change in combustion enthalpy (∆H), change in entropy (∆S) and the temperature (T):
Ketones may also have effects in neurons beyond their use as an energy source. Preliminary work shows ketones can affect neurotransmitter release, reduce inflammation in the brain and reduce damage caused by oxidative stress8. Whilst the strength of the clinical evidence supporting the use of ketosis varies according to the condition, future work should look to explore the efficacy and underlying mechanisms further. Ketosis (by diet or by exogenous ketones) could offer an intervention that has good efficacy, but without the side effects profile of many drugs currently in use. It should be noted that the use of ketogenic diet or exogenous ketones in the conditions discussed below is still classified as ‘experimental’ in the most part and so individuals should not their alter medication or diet without full medical supervision.  

KBs can cross the BBB but not in a homogenous manner. For example, past experiments have demonstrated that BHB utilization is different in various brain areas (Hawkins and Biebuyck, 1979). Areas without BBB, hypothalamic regions and the lower cortical layers have a higher BHB metabolism compared to the lower one of the basal ganglia (Hawkins and Biebuyck, 1979). Also the metabolic meaning of the three KBs is different: while the main KB produced in the liver is AcAc, the primary circulating ketone is BHB. The third one, acetone, is produced by spontaneous decarboxylation of AcAc, and it is the cause of the classic “fruity breath.” Acetone does not have any metabolic functions, but it can be used as a clinical diagnostic marker. BHB acid is not, strictly speaking, a KB because the ketone moiety has been reduced to a hydroxyl group. Under normal conditions the production of free AcAc is negligible and this compound, transported via the blood stream, is easily metabolized by various tissues including skeletal muscles and the heart. In conditions of overproduction, AcAc accumulates above normal levels and a part is converted to the other two KBs. The presence of KBs in the blood and their elimination via urine causes ketonemia and ketonuria. Apart from being the fundamental energy supply for CNS, glucose is necessary for the replenishment of the quota of oxaloacetate, since this intermediate of the tricarboxylic acid cycle (TCA) is labile at body temperature and cannot be accumulated in the mitochondrial matrix. Hence it is necessary to refurnish the TCA with oxaloacetate via the anaplerotic cycle that derives it from glucose through ATP dependent carboxylation of pyruvic acid by pyruvate carboxylase (Jitrapakdee et al., 2006). This pathway is the only way to create oxaloacetate in mammals. Once produced by the liver, KBs are used by tissues as a source of energy (Fukao et al., 2004; Veech, 2004; McCue, 2010): initially BHB is converted back to AcAc that is subsequently transformed into Acetoacetyl-CoA that undergoes a reaction producing two molecules of Acetyl-CoA to be used in the Krebs cycle (Figure ​(Figure22).
A few variables were tested in conjunction with weight loss. One was initial insulin secretion, specifically to see if it had any affect on loss in each diet group. It did not. They had also checked a few genetic markers that were suspected to give dieters pre-dispositions to success either on low fat diets or low carb diets based on previous studies. However, genetics were shown to have no effect.
I’m not sure if I really understand the idea of exogenous Ketones putting ones body into a state of KETOSIS, in that their own fat cells will be burned for fuel. Won’t the body just use the exogenous ketones and energy and continue to use glucose sources as well? How does taking ketones, make the body burn it’s own fat stores? I always thought that one would have to be in a state of energy deprivation for the body to actually begin to use the TG in the fat cells to generate ATP. Please let me know what I’m missing…

I am not a doctor and this is not to be taken, interpreted or construed as medical advice. If you have poor liver or gallbladder function, it can be a good idea to take care of that prior to a high fat diet, yes. But a healthy high fat diet would not cause liver issues per se. These are just my own personal thoughts and not a prescription or a diagnosis or any form of health care whatsoever.
So I slowly began cutting back on the amount of fat I was eating and adding in more carbohydrates. Foods I had missed so much like yams, potatoes, rice, fruit, whole wheat bread became part of my every day eating. I started eating out again. I started enjoying pizza and cake with my family again. I stopped tracking my macros. I gained more energy. My bloating went away. But most importantly, I started loving myself again.

These findings are in line with another meta-analysis on 13 randomized controlled trials lasting at least six months comparing low-fat and low-carbohydrate diets. They noted that at six months, subjects who consumed less than 60 grams of carbohydrates per day had an average greater weight-loss of 8.8 lbs. compared to subjects on low-fat diets. [20] At one year, the difference had fallen to only 2.3 lbs. [20]


Let’s hold up a sec. Allow me to introduce you to the DIETFITS Randomized Clinical Trial, published in February 2018 in the Journal of the American Medical Association. DIETFITS, which stands for Dietary Intervention Examining the Factors Interacting with Treatment Success, succeeded in busting a slew of dietary theories. Microbiome is responsible for everything? Nope. Predisposition to success on one diet based on genetics? Nah. Low carb over low fat? Uh-uh.


So I slowly began cutting back on the amount of fat I was eating and adding in more carbohydrates. Foods I had missed so much like yams, potatoes, rice, fruit, whole wheat bread became part of my every day eating. I started eating out again. I started enjoying pizza and cake with my family again. I stopped tracking my macros. I gained more energy. My bloating went away. But most importantly, I started loving myself again.
The high fat content in the diet, especially if you’re eating saturated fats, can raise your cholesterol levels and contribute to developing cardiovascular disease. Without the fiber from whole grains and fruits, you’re also likely to get constipated and have other digestive issues. Plus you need fiber to maintain a health gut microbiome, which tends to come from the kind of whole grains that you can’t eat on the diet, and though it is possible to get enough fiber from vegetables on the keto diet you have to carefully monitor your eating to ensure that. Neither Giancoli nor Fung any of the other dietitians and nutritionists who evaluated keto for a recent US News & World Report diets ranking would recommend it. Many of them said they had serious concerns about long-term safety of doing keto. Though you may very well lose weight, most people on most diets gain the weight back (and sometimes even more) when they go off the diet, which many dieters do because radical shifts in what you eat are hard to maintain for long periods of time.
Other kinesiologists think the keto diet could have dangerous effects on athletic performance, and it's tough to know what potential side effects a long-term high-fat diet might have for a healthy person, since we don't have any solid study results yet. Low-carb diets like keto can make it easy to neglect key nutrients like magnesium, calcium, and potassium found in fresh, high-carb foods like beans, bananas, and oats.
Let’s hold up a sec. Allow me to introduce you to the DIETFITS Randomized Clinical Trial, published in February 2018 in the Journal of the American Medical Association. DIETFITS, which stands for Dietary Intervention Examining the Factors Interacting with Treatment Success, succeeded in busting a slew of dietary theories. Microbiome is responsible for everything? Nope. Predisposition to success on one diet based on genetics? Nah. Low carb over low fat? Uh-uh.
Note to all potential buyers: these are meant to support a ketogenic diet (no carb, high fat, moderate protein), a specific diet which takes time and dedication to engage in. These are not “silver bullets” that will cause rapid weight loss without diet and exercise, so don’t expect it. No such products exist, on Amazon or otherwise. On the other hand, if you’re following a ketogenic diet already and need a little boost every now and then, these are for you. Watch out, though, they have a lot of caffeine. Three pills have 200 mg, the equivalent of several cups of coffee. If you can tolerate it, go for it. Just don’t make a regular habit of it.