I never respond to anyone online, but I felt compelled to respond to this. First off, rice and corn are grains. I’ve found since doing the ketogenic diet, was that my g.i. issues disappeared. Something is happening with breads, certain fibers, and grains. Within 6 weeks, my severe abdominal pain and cramping and “D” went away. My heartburn and indigestion disappeared, and I no longer experience “slow digestion” (I have no other way to explain what I was feeling”. My IBS symptoms are gone. I was able to get off the antispasmodic drugs my doctor had me try. I feel this way of eating is going to have to be a permanent lifestyle change. I was able to lose 45 lbs in the first 8-10 months, bring my a1c down from 5.8 to 5.0. I’m absolutely a firm advocate for the keto way of eating. I’m not dissing on anyone who is against this way of eating, I’m just saying that my symptoms from the past 25 years, I believe were totally due to the poor diet I used to have. Pizza, cake, ice cream, cookies, chips, poptarts, crackers, tv dinners, corn, potatoes, rice, beans, pasta and breads….when I find myself wishing for those things, I think of how I used to feel. Also….I got severe “hemmies” when I had my children, and they stayed with me. Since I’ve been eating the “keto way”, I’ve not had any hemmorhoidal (sp) flare ups. I spoke with my doctor, he’s on board with this diet if it means no more pain, or “D” or “H”. Everyone is different. I just happened to stumble upon this way of eating purely for my a1c. I was pleasantly surprised when my health issues went away too. If anyone else reading this has G.I. troubles, speak with your doctor about this way of eating. What was right for me may not be right for you. I’ve been doing keto for 2 years now. The weight has stayed off, and my tummy troubles have been kept at bay. Thank you for letting me ramble!
The first group of 75 consumed a low-carbohydrate diet with less than 40 grams of carbohydrates per day. The second group of 73 consumed a low-fat diet with less than 30% of calories from fat and less than 7% of calories from saturated fat. Both groups regularly received nutritional counseling periodically throughout the study meeting with each participant meeting with a dietitian for a total of 10 sessions

Y. Wady Aude, MD; Arthur S. Agatston, MD; Francisco Lopez-Jimenez, MD, MSc; Eric H. Lieberman, MD; Marie Almon, MS, RD; Melinda Hansen, ARNP; Gerardo Rojas, MD; Gervasio A. Lamas, MD; Charles H. Hennekens, MD, DrPH, “The National Cholesterol Education Program Diet vs a Diet Lower in Carbohydrates and Higher in Protein and Monounsaturated Fat,” Arch Intern Med. 2004;164(19):2141-2146. http://archinte.jamanetwork.com/article.aspx?articleid=217514.


Normal body cells metabolize food nutrients and oxygen during cellular “respiration”,  a set of metabolic pathways in which ATP (adenosine triphosphate), our main cellular energy source is created. Most of this energy production happens in the mitochondria, tiny cell parts which act as powerhouses or fueling stations. There are two primary types of food-based fuel that our cells can use to produce energy:


“For events longer than 60 minutes, consuming 0.7 g carbohydrates·kg-1 body weight·h-1 (approximately 30-60 g·h-1) has been shown unequivocally to extend endurance performance. Consuming carbohydrates during exercise is even more important in situations when athletes have not carbohydrate-loaded, not consumed pre-exercise meals, or restricted energy intake for weight loss. Carbohydrate intake should begin shortly after the onset of activity; [and continue] at 15- to 20-min intervals throughout the activity.”
Ketosis is an energy state that your body uses to provide an alternative fuel when glucose availability is low.  It happens to all humans when fasting or when carbohydrate intake is lowered.  The process of creating ketones is a normal metabolic alternative designed to keep us alive if we go without food for long periods of time. Eating a diet low in carb and higher in fat enhances this process without the gnawing hunger of fasting.
The brain is different as it is dependent on carbohydrates as a fuel source. This is because fats cannot easily cross the blood-brain barrier. The inability to make use of energy within fat poses a problem during periods where there is limited carbohydrate in the diet. If blood glucose levels fall to low, brain function declines. Relatively little energy is stored as carbohydrate (2,000 kCal) compared to fat (150,000 kCal). The body's store of carbohydrates runs out with a few days of carbohydrate restriction. Once glycogen is depleted, a cascade of hormonal signals causes the body to increase the release of stored fats (from adipose tissue). Signals include the fall in blood insulin, rise in a hormone called glucagon and an increase in cortisol (stress hormone) 1. The increase in blood fatty acids is a key trigger for ketone production (ketogenesis). Unlike fats, ketones are readily used as a fuel in the brain. Fatty acids are converted into ketone bodies in the liver, and ketones can provide up to 60% of the brain's energy requirements during starvation 2. The graph below shows how BHB (black triangles) builds up in the blood over many days until it reaches a level of around 6 mM.
Concussion (a mild form of TBI), is defined as a short term impairment of brain function caused by impact. Symptoms include dizziness, confusion and headache. When the brain suffers a concussive impact this triggers an acute cascade of cellular events that can eventually cause chronic problems. Firstly, immediately after impact there are changes to the concentrations of ions and neurotransmitters in and outside of the neurones. For example, the cells release potassium and glutamate (excitatory neurotransmitter); this can cause neuronal damage instantly64. The disruption to the equilibrium of substances within the brain must be corrected, which requires the action of the ATP dependant ion pumps in the cell membranes. In order to produce enough ATP the brain has a transient period of high glucose metabolism (within 30 minutes of impact), which is followed by a period of glucose metabolic depression that can last anywhere from 5 days to several months, depending on severity65. In this time the brain is starved of energy when it is unable to metabolise glucose, which can cause long term damage. Severe or repeated impacts can lead to development of conditions such as chronic traumatic encephalopathy (CTE). 
Rami co-founded Tasteaholics with Vicky at the start of 2015 to master the art of creating extremely delicious food while researching the truth behind nutrition, dieting and overall health. You can usually find him marketing, coding or coming up with the next crazy idea because he can’t sit still for too long. His favorite book is The 4-Hour Workweek and artist is Infected Mushroom.

Ketosis occurs when the body turns to fat as its main source of energy instead of carbohydrates, says Amy Shapiro, RD, the New York City–based founder of Real Nutrition. Keeping the body in ketosis for extended periods of time may lead to weight loss, according to a study published in Experimental & Critical Cardiology. Ketosis is a natural metabolic state in which the body burns fat rather than carbs.
Thanks for your comment. I’ve listened to the same experts you have…but we can’t just listen to those experts, we have to look at the actual science as well and play devil’s advocate. The claims the so called keto “experts” make aren’t all supported by fact and science. They can easily site studies that support their claims, but there are also studies that don’t. It’s called cherry picking. So please don’t say I’m uneducated or I haven’t done my research, because I have. Keto does not affect everyone in the SAME way! Some people’s cholesterol may go down, but some people’s may go up. That’s a fact. We can’t paint everyone with the same brush and say that for everyone, Keto improves cholesterol.
An interview with University of Florida researcher and scientist Dominic D’ Agostino. In that episode, “A Deep Dive Into Ketosis: How Navy Seals, Extreme Athletes & Busy Executives Can Enhance Physical and Mental Performance With The Secret Weapon of Ketone Fuel“, Dominic highlights his research into the use of ketones to enhance breathhold time and reduce the brain’s requirements for oxygen.
In addition to helping with weight loss, the Keto Diet has been used to treat epilepsy[9], help with Type II diabetes[10], polycystic ovary syndrome [11], acne [12], potential improvement in neurological diseases (Parkinson’s[13] and multiple sclerosis[14]), certain types of cancer[15], and reduces the risk factors in both respiratory and cardiovascular diseases[16]. Emerging studies are digging into its effects on Alzheimer’s [17]and other conditions as well.
Thank you for sharing, my husband and i have switched to the keto diet and we love it, we don’t feel restricted at all when it comes to meal planning, i actually feel like we eat more adventurous because we’re always looking for more receipts on how to prepare food. I’ve always done the same dinners, meat, veggies and a rice or pasta side, but with this diet we get to experiment, each night is something new to try. The Ketogenic diet is not about cutting all carbs, just cutting way back on carbs. We have gone and had regular check ups at the doctor with no negative results. I for one have always had an issue with poor digestion but since switching to the keto diet that has drastically changed. The hardest part for me was to cut pasta but i found great joy and fun in finding alternatives to pasta so i can still enjoy the same dish minus the carbs. There are so many different diets out there and so many different types of people so you have to find the right one for you, the keto diet is not for everyone but for us, so far it seems beyond perfect. Thank you again for sharing!

THANK YOU! I’ve been doing Keto for 3 weeks and I don’t think this is the diet nor lifestyle for me. I’ve been having on and off Keto Flu that included painful headaches and constant bowel issues. I thought it would be over by the end of week 1, but I continued so I thought again at the end of week 2, but continued. It’s the end of week 3 and I’m not seeing any changes. I’m feeling just as tired if not more than when I wasn’t on Keto. My mood has been more snappy and aggressive than when I wasn’t on Keto. I just wasn’t happy. I already was super sensitive to salt & salty foods and now I’m even MORE sick of salt & salty foods. I missed my fruits and veggies like carrots which my pup & I often snacked on. I got super gassy and burped more these past 3 weeks than my entire life. My period was a mess and came 4 days earlier than normal and I haven’t had an odd period in over a year after getting diagnosed with mild PCOS. Attempting Keto really threw my body in for a loop and it’s been down hill ever since. I haven’t dropped in weight, the inches are still there, the bloating is still there. But now I have this fear of eating. I used to miss meals before and did IF for a while but now I miss even MORE meals and rarely eat which is just a recipe for weight gain when you’re consuming high fat. I’ve stocked my fridge with items I rarely ever bought: Sour Cream, Bacon, Cream Cheese, Heavy Whipping Cream. All because I needed to hit my fat macros.
As is in the case of GABA, the intracellular reactive oxygen species (ROS) hypothesis works against the hunger-suppressive role of KD: it has been demonstrated that the hypothalamic ROS increase through NADPH oxidase is required for the eating-inhibitory effect of insulin (Jaillard et al., 2009); moreover it has been demonstrated that there is a ROS-dependent signaling pathway within the hypothalamus that regulates the energy homeostasis, and that activation of ROS-sensitive mechanisms could be sufficient to promote satiety (Benani et al., 2007). On the other side, KBs decreases mitochondrial production of ROS by increasing NADH oxidation in the mitochondrial respiratory chain (Maalouf et al., 2007).
Thanks for all of the great info!! I have Hashimoto’s and would really like to try a high fat/low carb diet. You mentioned that this might not be a good option for people with thyroid issues. How do you recommend I modify my diet to lose weight taking into consideration the Hashimoto’s. I take Westhroid, a non-synthetic thyroid supplement to help with my sluggish thyroid. Thanks so much for any advice you can give me. :)
Excellent post. I am of the “everything in moderation” crowd and I have been looking at some of the ketosis ideas and part of me thought… maybe. But after reading this I feel yes, keep with your current course. There’s no reason to get all stressed about eating again! Your attitude will help others find the right path for them and happy is healthy!

There are two main types of diabetes. In Type I diabetes, the insulin producing cells in the pancreas are destroyed by an immune response resulting in insulin deficiency. In Type II diabetes insulin is still secreted, but the cells in the body no longer respond adequately and so glucose uptake is not triggered. Sometimes pregnancy can trigger a period of diabetes (gestational diabetes), which resolves after giving birth. 
In 2014, a group of three Brazilian researchers assessed the available literature on low-carbohydrate diets in a meta-analysis. They specifically looked at trials that compared a very-low carbohydrate ketogenic diet (VLCKD) that contained no more than 50 grams of carbohydrates per day against a conventional, low-fat diet with less than 30% of calories from fat. Ultimately, they included 13 studies that lasted 12 months or more and collectively contained 1577 subjects with 787 randomized to a low-fat diet group and 790 to a VLCKD group.
Many people may look at my side-by-side before and after pics and think, "She was fit before and she looks the same now." (Isn't it strange how differently other people see you versus how you see yourself?) But eating and exercise should always be about more than the aesthetics. How do your diet and fitness habits make you feel? Food is fuel (and recovery) for the activities you like to do most. If eating well means you gain some perspective, then ending up with a better butt is just icing on the cake. BTW, I can have cake now. 

I'm officially at the half way mark in my 2-week #ketogenicdiet, and I'm just now feeling like a complete human. The first 3-4 days I was seriously drained (#CardioIsHardio is putting it lightly), which is what I've heard to expect in the beginning. But this weekend, I hit up my go-to #barre studio, did some speed intervals on the bike, and got in some #kettlebell training, too. Ready to tackle this last week of #keto...then eat all the . Jk, kinda. #keto360 #healthyfats #ketosis

For patients who benefit, half achieve a seizure reduction within five days (if the diet starts with an initial fast of one to two days), three-quarters achieve a reduction within two weeks, and 90% achieve a reduction within 23 days. If the diet does not begin with a fast, the time for half of the patients to achieve an improvement is longer (two weeks) but the long-term seizure reduction rates are unaffected.[43] Parents are encouraged to persist with the diet for at least three months before any final consideration is made regarding efficacy.[9]
Question: I have recently done my 23&me DNA test and have also put my info into AthletiGen. I’m curious about your thoughts about high fat/low carb diet in context of this info. My test says I am ‘2x more likely to loose weight on a low fat diet’, and that I have ‘normal sensitivity to weight gain due to saturated fat intake/and unsaturated fat intake’, & ‘likely to eat normal amounts of carbs’! All interesting but in the ketosis context, I took this to mean that eating high fat/low carb would not be of greatest benefit to me?! (I have tried getting into ketosis prior to all the new supps, for about 3 months, and I couldn’t get in to it (tested w/ blood finger prick) and didn’t feel great). Which leads me to wonder what Macro ratio would be best, as I’m also a endo-meso)!

We now know the ketogenic diet has many other therapeutic benefits. One of them being that it trains the body to burn fat (in place of sugar) for fuel making the ketogenic diet an excellent choice for weight loss and improvement in body composition. The ketogenic diet is also excellent at treating and preventing insulin resistance like as found in type 2 diabetes and can even lower diabetic medication dosage or even prevent one’s need for blood sugar lowering medication. Weight loss through a ketogenic diet can also help lower cholesterol and triglycerides and improve overall cardiovascular function as well.

Ketolysis is the process of breaking down ketones to ultimately provide energy through the Krebs Cycle and mitochondrial oxidative (using oxygen) phosphorylation. Ketone bodies are broken down in the mitochondria of virtually all tissues in the body. The liver is a notable exception, being unable to utilise ketones as a fuel because liver cells lack acetyl-CoA thiolase, a key enzyme in the ketone oxidative pathway. BHB enters the mitochondria of the cell through a monocarboxylate transporter, undergoes conversion to acetoacetate by BHB dehydrogenase and then addition of a CoA group from succinyl-CoA by 3-oxo-acid transferase. The resulting acetoacetyl-CoA acts a substrate for the formation of two molecules of acetyl-CoA in a reaction catalysed by acetyl-CoA thiolase. Acetyl-CoA is then available to condense with oxaloacetate and enter the Krebs cycle.
And it all culminated with me stepping into Dr. Jeff Volek’s world famous laboratory at University of Connecitut to subject myself to extensive blood testing, chunks of muscle removed from my legs, fat sucked out of my butt-cheeks, urine, stool and gut microbiome testing, oxygen and carbon dioxide testing and countless hours of treadmill running to discover what a full twelve months of eating a ketotic diet had actually done to my body.
Day 2: There's a bagel shop less than a block from my office. I pass it every single day and never really think anything of it. Well, not today! The smell of the freshly baked everything bagels—and was that veggie cream cheese I smelled?—was wafting out the door as I walked by extra quickly. (Though I found out later that there is a way to have bread and still stay in ketosis.) 
The authors noted that “weight loss was similar between groups” [21]. However, they emphasized that “effects on atherogenic dyslipidemia (cholesterol) and glycemic control were still more favorable with a low-carbohydrate diet after adjustment for differences in weight loss.” [21] Another study noted that the low-carb diet promoted greater weight-loss than a standard low-fat diet for the first six months. However, these differences were small after one year. [22]
The state of ketosis occurs when ketone bodies, which are actually three biochemicals -- acetone, acetoacetic acid and beta-hydroxybutyric acid -- build up in your bloodstream. Your body needs carbohydrates to fully break down fat, so a lack of carbohydrates in your diet leads to ketosis. It is normal for the body to produce small amounts of ketone bodies, but when placed in a state of starvation, the liver produces ketone bodies from fatty acids to nourish essential organs like the brain and heart. The excess acetone is excreted in the urine and producing the characteristic sweet breath often found in diabetics
The Gatorade Sports Science Institute (GSSI) is widely considered one of the world’s top go-to resources for cutting-edge exercise and nutrition science advice – which is probably why Gatorade vending machines dot the campus here, and the majority of the kids seem to be walking around campus with a never-ending big gulp-sized cup full of sports drink.
“Instead of engaging in the next popular diet that would last only a few weeks to months (for most people that includes a ketogenic diet), try to embrace change that is sustainable over the long term. A balanced, unprocessed diet, rich in very colorful fruits and vegetables, lean meats, fish, whole grains, nuts, seeds, olive oil, and lots of water seems to have the best evidence for a long, healthier, vibrant life."

Hi Ben, I have a question about being in ketosis. So from what I understand, a serving of Keto os will keep you in ketosis for about 4-6 hours or so……my question is doesn’t your body have to be in constant ketosis in order to really experience the benefits of using the fat as fuel? Also, if someone is not following the Keto diet, what happens to the glucose they are still consuming if they are supposedly using ketones for energy? Also, do you see any benefit from using Keto os vs. Brain Octane? I ask because there is a significant difference in price. Thank you so much!!


In addition, most studies that compare carbohydrate utilization with fat utilization fail to take into account the fact that full “fat adaptation” that allows you to gain all the benefits of using fat as a fuel actually takes time – often more than four weeks – and up to a couple years. But since most studies that compare fat and carbohydrate burning are short-term, you rarely see the benefits of this kind of fat adaptation actually fleshed out in research. Instead, the average research participant begins the study in a non-fat adapted state, gets either a high fat or high carb diet, then launches into exercise. But in an ideal study, that person would have followed either a high-fat or high-carb diet for many months before getting their fat burning capability investigated.

I am an insulin dependent diabetic. I have been on a modified keto diet – mainly low-carbohydrate, increased good fats, and moderate protein. Though I have not lost any weight, my blood sugar stays in my target range and I have decreased my short term insulin intake by 75%. I see this as a good outcome. I would like to lose weight because I have arthritis and I think it would help my joints not to have to carry so much weight around. I am about 30 pounds overweight. What do you think of Low carbuhydratev for people who are diabetic and benefit so much from Keto ,I also practice intermittent fasting.
Thank you for this honest post on how Keto affected you. I did Keto for 6 weeks. I did lose 7 lbs but I struggled with depression and not using the bathroom regularly nice I started the diet. I searched and found carbs help with serotonin uptake which explained my depression. Everywhere I look people are pro Keto instead of discussing some the side effects. My gym friend told me she cried the last 4 days she did Keto before saying enough is enough. If it works for others, that’s great, but it’s refreshing to hear that I am not the only one who struggled and stopped Keto.
If you’re looking to slim down in a healthy way, the ketogenic diet plan for weight loss just might be for you! In case you’re not familiar with the plan, the keto diet is a low carb diet that forces your body into a metabolic state. It pretty much turns your body into a fat-burning machine! Ketosis is a natural process in the body that helps us survive when food intake is low. During ketosis we produce ketones in the liver to be used as energy and fuel throughout the body, including the brain.
A high-fat diet also trains your body to burn even more fat during exercise, even at high intensities. Fat is released faster and in greater amounts from your storage adipose tissue and transported more quickly into your muscles and mitochondria. Your muscles also store more energy as fat and use this fat-based fuel more efficiently and quickly. Even more interestingly, a high-fat diet can cause a shift in the gene expression that codes for specific proteins that increase fat metabolism – and create very similar adaptations to exercise itself. So the mere act of shifting primary fuel intake from carbohydrates to fat begins to make you more “fit”, even if you’re not exercising.
A high-fat diet also trains your body to burn even more fat during exercise, even at high intensities. Fat is released faster and in greater amounts from your storage adipose tissue and transported more quickly into your muscles and mitochondria. Your muscles also store more energy as fat and use this fat-based fuel more efficiently and quickly. Even more interestingly, a high-fat diet can cause a shift in the gene expression that codes for specific proteins that increase fat metabolism – and create very similar adaptations to exercise itself. So the mere act of shifting primary fuel intake from carbohydrates to fat begins to make you more “fit”, even if you’re not exercising.
"I start my day with coffee and heavy whipping cream. My first meal of the day is in the afternoon and is usually something small like leftovers or some eggs. It’s about getting in protein and making sure whatever I eat is quality and tastes delicious. For dinner, I have a bigger meal which is always an animal protein with a side of something green like spinach or broccoli."

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