But comprehensive transcriptional profiling of glucose-sensing neurons is challenging, as glucokinase (Gck) and other key proteins that transduce glucose signals are expressed at low levels. Glucose also exerts a hormonal-like action on neurons; electrophysiological recordings demonstrated, for example, that hypoglycemia activates growth hormone-releasing hormone (GHRH) neurons, suggesting a mechanistic link between low blood glucose levels and growth hormone release (Stanley et al., 2013).
These are the widely recognized LCT’s, or long chain fatty acids in coconut oil, mostly saturated, including stearic acid (C18:0), oleic acid (C18:1), and linoleic acid (18:2). The exact percentage of each depends on region the coconut is grown, time of harvest, and other growing variables. They are good as a fuel source in your food, and have some of the tastiness of coconut oil, if your goal is getting into ketosis fast, you won’t benefit from eating a lot more of them compared to eating true medium chain fatty acids.
The more I read about the bad side of the Keto diet, the more I fear for my younger brother & s-i-l. They’re on it now & have lost weight. But….my fear is for my brother, who had one of his kidneys removed (non-functioning) about 2 years ago. I believe he is being monitored, but I don’t think he should be on it. Too many things could go wrong for him.
Gosh I remember the feelings I had before I started keto... feelings of fear, feelings of being discouraged or letting myself down again... what if I fail at this like I have with every other thing I’ve tried the past 12 years. Looking back a year ago on Mother’s Day reflecting where I was then to where I am now not just my weight loss but also my mental state at the time. Things were better but I was no where near where I am now. The weight loss and drastically changing my eating habits have all contributed and I’m so thankful I made myself show up everyday. So what if? What if I never gave myself the chance? I preach believing in yourself a lot because you are the only one who can push yourself to make the change. No one else just you. Don’t let the what’s ifs hold you back. Believe in YOU. Show up for YOU. Tip toe if you must but if it’s something you want soooo bad... everyday wake up and TAKE THAT STEP! It’s worth it💕 Happy #transformationtuesday 🌸
The Keto diet emphasizes weight loss through fat-burning. The goal is to quickly lose weight and ultimately feel fuller with fewer cravings, while boosting your mood, mental focus and energy. According to Keto proponents, by slashing the carbs you consume and instead filling up on fats, you safely enter a state of ketosis. That’s when the body breaks down both dietary and stored body fat into substances called ketones. Your fat-burning system now relies mainly on fat – instead of sugar – for energy. While similar in some ways to familiar low-carb diets, the Keto diet’s extreme carb restrictions – about 20 net carbs a day or less, depending on the version – and the deliberate shift into ketosis are what set this increasingly popular diet apart.
My dad was diabetic even though he was a competitive cyclist and ate "healthy". I grew up in a Weight Watchers household where everything was sugar-free and fat-free. Back then, if you had diabetes, you switched your white bread, rice, and pasta to whole wheat and you were fine. My dad died of pancreatic cancer when I was 19 years old. They say there’s no cause for this cancer, but I think the stress from his diabetes on his pancreas had a lot to do with it.
This was a great post. I did Keto last year, really strictly, and dropped 13 lbs in about 3 weeks. Then the holidays came and I had cookies. I’ve struggled since then to get back into the Keto mode. I do well for a few days, drop a few lbs and then have a “bad” weekend and back up I am. I’ve literally been gaining and dropping the same 5 lbs. for a year. I also miss certain carbs. I love bread and homemade bread can be healthy. I miss yams and beans, etc. I’m beating myself up because I want these foods I’ve eaten my entire life and now “can’t”. I appreciate your comments about accepting and loving our bodies no matter what size. Yes, I want to be healthy but I’m tired of obsessing about every single thing that I put in my mouth. This article is inspiring.

In other words, I personally found that while following “strict ketosis”, things became eerily similar to the days in college when I was a competitive bodybuilder pursuing sub-3% body fat percentages. I simply wasn’t the most fun guy to hang out with in social situations due to my extreme dietary restrictions, the intense self-control became nearly exhausting, and when I traveled, I missed out on many culinary experiences, such as homemade ravioli in Rome, freshly baked crostinis in the Basque regions of Spain, and Korean rice bowls in Seoul.
At the end of the twelve months, 60 participants (about 82%) in the low-fat group and 59 participants (about 79%) in the low-carbohydrate group successfully completed the trial. The decrease in body weight was substantially greater in the low-carbohydrate diet group which lost four times as much weight as the low-fat group (1.1 kg vs. 4.4 kg). [18]
This is why Gaspari Nutrition chose highly branched cluster dextrin for what we consider to be the gold standard of recovery and performance drinks. This high molecular weight carbohydrate has a special helical structure, which gives it unique properties unlike many of the corn starches or polysaccharides out there. I'll be real with you and say this stuff isn’t cheap, but you certainly pay for what you get, and highly branched cluster dextrin is unlike any carb source I've found – especially if you want to control blood sugar levels and gut issues.
Given the choice of a fat and protein source like meat or a salt and carb rich food like potato chips, we are designed say yes to both. No matter how stuffed we are, the most primal parts of our brain will typically tell us that there is room for more if a novel food source is available. These behaviors were essential for our survival as a species. If we ate reasonably whenever food was available, then we wouldn’t have enough fat or muscle to fuel us when calories were scarce.
Acetyl-CoA can be metabolized through the TCA in any cell, but it can also undergo a different process in liver cells: ketogenesis, which produces ketone bodies.[27] Ketone bodies are also produced in mitochondria, and usually occur in response to low blood glucose levels.[28] When glucose levels are low, oxaloacetate is diverted away from the TCA cycle and is instead used to produce glucose de novo (gluconeogenesis). But when oxaloacetate is unavailable to condense with acetyl-CoA, acetyl-CoA cannot enter the cycle, and so the body has evolved an alternative way to harvest energy from it.
Meanwhile, the KD induces a ketosis that is not a pathological but physiological condition occurring on a daily basis. Hans Krebs was the first to use the term “physiological ketosis” despite the common view of it as oxymoron (Krebs, 1966); this physiological condition, i.e., ketosis, can be reached through fasting or through a drastically reduced carbohydrate diet (below 20 g per day). In these conditions, glucose reserves become insufficient both for normal fat oxidation via the supply of oxaloacetate in the Krebs cycle and for the supply of glucose to the central nervous system (CNS) (Felig et al., 1969; Owen et al., 1969) (Figure ​(Figure1).1). It is well-known that the CNS cannot use FAs as an energy source because free FAs cannot cross the blood-brain barrier (BBB). This is why the brain normally uses only glucose. After 3–4 days without carbohydrate intake (KD or fasting) the CNS must find alternative energy sources as demonstrated by Cahill et al. (Owen et al., 1967, 1969; Felig et al., 1969; Cahill, 2006). These alternative energy sources are the ketones bodies (KBs): acetoacetate (AcAc), β-hydroxybutyric acid (BHB) and acetone and the process of their formation occurring principally in the mitochondrial matrix in the liver is called ketogenesis (Fukao et al., 2004). Usually the concentration of KB is very low (<0.3 mmol/L) compared to glucose (≅ 4 mmol) (Veech, 2004; Paoli et al., 2010). Since glucose and KB have a similar KM for glucose transport to the brain the KB begin to be utilized as an energy source by the CNS when they reach a concentration of about 4 mmol/L (Veech, 2004), which is close to the KM for the monocarboxylate transporter (Leino et al., 2001).
Happy #transformationtuesday ! The picture on the left is from my college graduation. I was 21 years old and 264 lbs. It was taken the same month I started this weight loss journey. Today, I am 27 and weigh 151 lbs. Stating out, I knew nothing about keto! I did research and asked questions and has a lot of trial and error. If I can do this, anyone can! Keep pushing!! 😘😘
modified corn syrup, palm sugar,dextrin, fruit juice concentrate to name a few. People need to wake up. I learned the hard way. I got gout from drinking Vitamin Water-32 grams of sugar per bottle which equals 8 tsp. of sugar per bottle. Next time you buy pop or fruit juice or some processed food check for carbs. Our western diet is turning us into an obese society full of diseases. I find this very sad especially for the next generation. I truly believe a low carb diet could turn this around. I love Keto and all the great recipes and I will stay on it for the rest of my life. I am now off all medication and feeling great.

Type II diabetics can reduce their risk of developing these complications by keeping blood glucose levels within a healthy range (4.5 - 6.5 mM). This can be achieved using insulin injections, but using insulin is not without side effects (i.e hypoglycemia requiring assistance and weight gain)101. Therefore dietary carbohydrate restriction is likely to be a good lifestyle change to help with diabetes management,. Companies such as Virta Health are popularising this approach to diabetes management and pioneering the use of technology to improve compliance. The benefits of carbohydrate restriction include:

A randomized control study in 2017 examined the effects of a ketogenic diet combined with Crossfit training on body composition and performance. Results from this study concluded that subjects following a low-carbohydrate ketogenic diet (LCKD) significantly decreased body weight, body fat percentage and fat mass compared to those in the control group[*].